Kapelios CJ, Laroche C, Crespo‐Leiro MG, et al. - Given that guidelines advise down‐titration of loop diuretics (LD) once euvolaemia is attained, researchers performed this study with outpatients with heart failure (HF) to determine LD dose alterations in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down‐titration as well as link between dose alterations and results. The ESC‐EORP Heart Failure Long‐Term Registry was used to identify 8,130 HF patients. In patients who had dose reduced, experts defined successful reduction as the decrease not followed by death, HF hospitalization, New York Heart Association class deterioration, or subsequent rise in LD dose. Among outpatients with chronic HF, 76% and 8.3% had no change and reduction in diuretic dose, respectively. Worse outcomes were observed in relation to LD dose increase, while a trend for better results was noted in the LD dose decrease group vs the no‐change group. Factors that showed independent link with successful dose reduction were: higher systolic blood pressure, and absence of (i) sleep apnoea, (ii) peripheral congestion, and (iii) moderate/severe mitral regurgitation.