Kapelios CJ, Laroche C, Crespo‐Leiro MG, et al. - Given that down‐titration of loop diuretics (LD) has been advised by guidelines once euvolaemia is achieved, so, researchers focused on LD dose alterations in daily cardiology practice in outpatients with heart failure (HF). They also investigated agreement with guideline suggestions, predictors of successful LD down‐titration as well as link between dose changes and results in this patient population. Using the ESC‐EORP Heart Failure Long‐Term Registry, a total of 8,130 HF patients were identified. In this patient sample, diuretic dose was unchanged and was reduced in 76% and in 8.3%, respectively. Worse outcomes were observed in relation to LD dose increase, while a trend for better results was demonstrated by the LD dose decrease group vs the no‐change group. Factors that were identified to be independently related to successful dose reduction were: higher systolic blood pressure, and absence of (i) sleep apnoea, (ii) peripheral congestion, and (iii) moderate/severe mitral regurgitation.