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Association between central blood pressure and subclinical cerebrovascular disease in older adults

Hypertension Jan 06, 2020

Matsumoto K, Jin Z, Homma S, et al. - Researchers here investigated the association between central BP and silent cerebrovascular disease. Two-dimensional echocardiography, arterial wave reflection analysis were undertaken for determination of central BPs, and brain magnetic resonance imaging was performed among participants in the CABL (Cardiovascular Abnormalities and Brain Lesions) study (n = 993; mean age, 71.7±9.3 years; 37.9% men). Central BPs were calculated from the radial pulse waveform. Silent brain infarction and white matter hyperintensity volume defined subclinical silent cerebrovascular disease. They observed an independent association of both brachial and central pulse pressure with silent brain infarctions in a predominantly older population-based cohort. However, they noted the significant association of higher central systolic BP and central pulse pressure, but not of brachial BP, with white matter hyperintensity volume.
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