Matsumoto K, Jin Z, Homma S, et al. - Researchers sought to determine the correlation of central blood pressure (BP) and brachial BP with subclinical cerebrovascular disease in a predominantly older population-based large cohort. From the CABL (Cardiovascular Abnormalities and Brain Lesions) study, 993 participants (mean age, 71.7±9.3 years; 37.9% men) were assessed; these had undergone 2-dimensional echocardiography, arterial wave reflection analysis for determination of central BPs, and brain magnetic resonance imaging. In this predominantly older population-based cohort, an independent association of both brachial and central pulse pressure with silent brain infarction was identified. However, white matter hyperintensity volume was observed in significant correlation with higher central systolic BP and central pulse pressure, but not with brachial BP. Findings here support the hypothesis of more direct involvement of central BPs than brachial BP in the pathogenesis of cardiovascular disease.