Qiao Y, Martinez-Amezcua P, Wanigatunga AA, et al. - Researchers examined how cardiovascular disease (CVD) risk and fatigability measured, on average, 4.5 years later, are associated with each other in a population of well-functioning middle-aged and older adults with no history of CVD. Further, they examined the independent correlations between fatigability and factors most commonly connected with CVD risk (eg, hypertension, hypercholesterolemia, diabetes mellitus, etc). From the Baltimore Longitudinal Study of Aging, they classified 625 participants with no history of CVD (aged 68.1+12.0 years) and with ≥ 2 clinic visits between 2007 and 2015, according to sex-specific predicted 10-year CVD risk scores using the Framingham CVD risk score (Framingham) and the Pooled Cohort Equation at baseline. Well-functioning older adults free of CVD showed a correlation of higher baseline CVD risk with higher levels of perceived fatigability an average of 4.5 years later. Strong associations with hypertension and obesity were observed suggesting the value of preventing and promoting cardiovascular health for lowering perceived fatigability, particularly among those aged ≤ 70 years or living with obesity.