Tully PJ, Yano Y, Launer LJ, et al. - Researchers examined the link between blood pressure variability (BPV) and cerebral small-vessel disease (CSVD). Since BPV and mean blood pressure are interrelated, it is not certain if BPV contributes additional information to understanding cerebrovascular morphological features. For this purpose, they conducted a systematic review from inception until March 3, 2019. They meta-analyzed 27 articles with 12,309 unique brain scans. They pooled 31 odds ratios, suggesting a link between higher systolic BPV and higher odds for CSVD independent of mean systolic pressure. Also, a link was identified between higher diastolic BPV and higher odds for CSVD independent of mean diastolic pressure. Based on evidence from the available studies, there was a link between BPV and CSVD independent of mean blood pressure. However, there is a need for more high-quality longitudinal data to clarify if BPV adds unique variance to CSVD morphological features.