Stolfo D, Uijl A, Benson L, et al. - Among patients aged ≥ 80 years suffering from heart failure (HF) with reduced ejection fraction (HFrEF) (ejection fraction < 40%), identified from the Swedish HF Registry, researchers examined the link between beta-blocker use and outcomes. They applied Cox proportional hazard models in a 1:1 propensity score-matched cohort to determine the link between beta-blocker use, all-cause death and cardiovascular (CV) death/HF hospitalization. They used a positive control cohort with age < 80 years to conduct the same analyses, to determine consistency. They also performed a negative control outcome analysis using hospitalization for cancer as endpoint. Findings revealed a high use of beta-blockers in HFrEF patients ≥ 80 years of age. In these patients, improved all-cause and CV survival were observed in relation to the use of beta-blockers. Decreased risk of all-cause mortality and of the composite outcome was observed in relation to beta-blocker use in patients aged < 80 years.