Luo H, et al. - Via a retrospective cohort study of a total of 2,969 people who use drugs (PWUD) with HIV were included from 1 January 1995 to 31 December 2014, the researchers examined the factors affiliated with disease progression following HIV diagnosis in PWUD. Either in patients with HIV or in subjects with AIDS, age at diagnosis, marital status, baseline CD4 T-cell counts and highly active antiretroviral therapy (HAART) were concluded as statistically important. In comparison with HIV-infected individuals of 18 years, subjects with AIDS who were at least 36 years of age maintained a sharply escalated HR for developing AIDS. In contrast to married subjects, the single HIV-positive people less likely to acquired AIDS. A correlation of raising baseline CD4 T-cell counts, HAART, and condom utility with postponed progression to AIDS was ascertained. Hence, it was discovered that raising baseline CD4 T-cell counts, HAART, and condom usage could be connected to delay in the progression of HIV to AIDS, whereas growing age at diagnosis, marital status enhanced the danger of developing AIDS. Moreover, public health and medical services are required to be upgraded for better targeting these risk factors to slow down disease progression.