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Assessment of exudative activity of choroidal neovascularization in age-related macular degeneration by OCT angiography

Ophthalmologica Nov 07, 2019

von der Emde L, Thiele S, Pfau M, et al. - Based on exudative activity, classification of choroidal neovascularization (CNV) in age-related macular degeneration (AMD) is as follows “active” aCNV, pretherapied “silent” sCNV (ie, a treatment-free interval > 12 weeks), or treatment-naïve “quiescent” qCNV. Researchers evaluated these CNV subgroups for the qualitative and quantitative optical coherence tomography angiography (OCTA) features. They included 51 eyes of 51 patients with AMD (age 75.9 ± 7.5 years; 20 males [39.2%]). The highest prevalence of qualitative and quantitative values for OCTA activity criteria was evident in the qCNV subgroup (n = 8), reaching significance with regard to small-caliber vessels, peripheral arcades, vessel length, and branching index when compared to the aCNV (n = 32) and sCNV (n = 11) subgroups. Outcomes support the possible supportive value of OCTA in the phenotypical differentiation of CNV lesions secondary to AMD, while the assessed structural changes seemed to be more suggestive of previously administered anti-VEGF therapy than current exudative activity.
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