Caprari E, et al. - Since lidocaine/tetracaine 7%/7% peel cream (L/T-pC) is very effective in reducing pain in several dermatological procedures like hair or tattoo laser removal or conventional photodynamic therapy associated pain, researchers performed a prospective, randomized, parallel-group, controlled, single-blind trial to evaluate the clinical effectiveness of L/T-pC in reducing pain during microablative fractional laser resurfacing treatment in individuals with facial skin ageing. In total, 30 individuals (4 men, 26 women; mean age 42 ± 10 years; range 28-57) with mild to moderate facial skin ageing (Glogau score ≥ 2), suitable for FLR treatment, were recruited after their written informed consent. Study participants were randomly assigned to either the L/T-pC application (45 minutes before the laser treatment with the removal of the cream just before the starting of laser session) (n = 20) or to control (emollient cream; n = 10). The use of L/T pC 7%/7% peel cream prior to a fractional laser resurfacing session significantly reduced procedure-associated pain while maintaining high tolerability and safety profile.