Vesga JF, et al. - Using a modelling approach to link tuberculosis (a complex and multifactorial disease) care cascade to transmission, researchers have identified which cascade improvements would have the greatest impact on incidence and mortality. Investigators have been involved with national tuberculosis programmes in three country settings (India, Kenya, and Moldova) as illustrative examples of settings with a large private sector (India), a high HIV burden (Kenya), and a high burden of multidrug resistance (Moldova). Modelling suggests that combined measures to reinforce the care cascade could decrease cumulative tuberculosis incidence by 38% in India, 31% in Kenya, and 27% in Moldova between 2018 and 2035. The cascade of care linked to the transmission can be valuable, not only to improve patient outcomes but also to identify and monitor programmatic priorities to reduce the incidence and mortality of tuberculosis.