Datta S, et al. - Researchers assessed the incremental cost-effectiveness of vaccinating boys as well as girls via analyzing human papillomavirus (HPV) infection and vaccination. They used an epidemiological model including sexual partnerships between individuals, matched to numerous HPV prevalence data sources to fit the parameters associated with HPV transmission. Then they used the parameters from the above model to simulate a range of vaccination strategies. Thirdly, they assessed the cost-effectiveness of each vaccination strategy via an economic analysis of the different strategies, taking into account potential consequences (including health-related quality of life and cost implications) of HPV infections. Findings suggest vaccinating girls vs no vaccination is very cost-effectiveness. Vaccinating both sexes is less cost-effective. Males have high protection through herd immunity, making their addition to an already successful girls-only program not very cost-effective.