Zaidi AH, et al. - As smaller ascending aorta diameter is associated with cerebral white matter (WM) microstructural abnormalities in neonates with single ventricle, researchers investigated if this association persists into adolescence. They assessed ascending aorta Z scores from first postnatal echocardiogram, and acquired brain magnetic resonance imaging with diffusion tensor imaging in adolescence to obtain fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity in 33 WM tract regions of interest. Adolescents with single ventricle displayed the association of smaller aorta diameter at birth with abnormalities of WM microstructure in a subset of WM tracts, mostly those located in deeper brain regions. This suggests a lasting influence of prenatal cerebral blood flow on WM microstructure in single-ventricle patients despite multiple intervening medical or surgical procedures,.