Belkin MN, Alenghat FJ, Besser SA, et al. - Utilizing individual‐level data from the ESCAPE trial (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness), researchers investigated whether aortic pulsatility index [API, calculated as (systolic–diastolic blood pressure)/pulmonary capillary wedge pressure], would better predict clinical results compared with conventional haemodynamic metrics of cardiac function. A composite endpoint of death or requirement for orthotopic heart transplant or left ventricular assist device at 6 months was considered as the primary outcome. The primary outcome was predicted by final API measurements, with an OR of 0.47, but not by cardiac index, cardiac power output, and pulmonary artery pulsatility index. In Kaplan–Meier analyses, API ≥ 2.9 was shown to be related to greater freedom from the primary outcome (83.5%), vs API < 2.9 (58.4%). Overall, in the ESCAPE trial, clinical results were better predicted by novel haemodynamic measurement API vs conventional invasive haemodynamic metrics of cardiac function.