Liu HL, et al. - This study hypothesized that a high ticagrelor loading dose (LD) may improve platelet inhibition in non-ST-elevation acute coronary syndrome (NSTE-ACS) patients undergoing percutaneous coronary intervention (PCI). Findings demonstrated that in this patient population, faster onset and greater platelet inhibition were achieved, without an increase in adverse events, as a consequence of doubling the ticagrelor loading dose.