Schumacher BML, et al. - Researchers performed this study on women who conceived naturally. Their goal was to investigate the link between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage. They found an inverse association between AMH levels and the risk of miscarriage. The miscarriage was most likely to happen in cases with severely diminished ovarian reserve.

Methods

• In this prospective cohort study, researchers included women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally.
• Miscarriage, defined as an intrauterine pregnancy loss before 20 weeks’ gestation was considered as main outcome measure.

Results

• They found that risk of miscarriage decreased as AMH increased (risk ratio per unit increase in natural log of AMH = 0.83; 95% confidence interval [CI], 0.73, 0.94) after adjusting for maternal age, race, history of recurrent miscarriage, and obesity.
• Findings also revealed that women with severely diminished ovarian reserve (AMH ≤ 0.4 ng/mL) miscarried at over twice the rate of women with an AMH ≥ 1 ng/mL (hazard ratio, 2.3; 95% CI, 1.3, 4.3).