Choi SY, Kim MH, Lee KM, et al. - A cohort of initially low‐risk patients with atrial fibrillation (AF)(CHA2DS2‐VASc score of 0 [male], 1 [female]) was studied in relation to their development of incident comorbidities and their treatment on oral anticoagulation therapy. Using the Korean National Health Insurance Service database, they assessed data from 14,441 low‐risk patients with AF (CHA2DS2‐VASc score of 0 [male] or 1 [female]), in relation to their development of incident stroke risk factors and adverse outcomes. Among the patients with an increasing CHA2DS2‐VASc score ≥ 1, a significantly lower risk of ischemic stroke, all‐cause death, and composite outcomes was observed in male and female patients treated with oral anticoagulants vs patients not treated with oral anticoagulants. Analysis revealed acquisition of ≥ 1 stroke risk factor by nearly 30% of patients over a 2‐year follow‐up period. Based on observations, they emphasize performing regular assessment of low‐risk patients with AF to adequately identify those with incident stroke risk factors that would merit thromboprophylaxis for the prevention of stroke and the composite outcome.