Anticancer drugs and cardiovascular-related hospitalization in metastatic colorectal cancer: Insights from the AVOCETTE population-based study
American Journal of Epidemiology Sep 26, 2020
Dolladille C, Launoy G, Bouvier V, et al. - This study was undertaken to evaluate the relationship between anticancer drugs and cardiovascular-related hospitalization (CVRH) in metastatic colorectal cancer (mCRC) patients. Researchers performed a cohort study using the French county Calvados registry of digestive tumors. They enrolled incident mCRC cases between 2008 and 2014. This research included a sum of 1,116 mCRC patients; they were administered 12,374 rounds of treatment; fluorouracil, oxaliplatin, irinotecan, and bevacizumab were most common. The data exhibited that CVRH was significantly correlated with higher all-cause mortality (multivariable hazard ratio for death 1.58, 95%CI 1.28-1.95). The evidence suggested that in mCRC patients, anticancer drugs were not correlated with a higher incidence of CVRH.
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