Sawai T, et al. – This study compared eplerenone with thiazide diuretics in terms of effects and safety in patients with hypertension and albuminuria (pretreatment urinary albumin/creatinine ratio ≥10 mg/gCr) treated with an angiotensin II receptor blocker. Findings demonstrated that eplerenone/thiazide diuretics plus an angiotensin II receptor blocker had similar antialbuminuric effects and safety in patients with hypertension and albuminuria.

Methods

• The primary end point of this study was the mean percent change in the urinary albumin/creatinine ratio from baseline to 48 weeks.
• Researchers also performed an efficacy analysis in 195 patients (98 in the eplerenone group and 97 in the thiazide group).

Results

• Findings demonstrated that systolic and diastolic blood pressures at 48 weeks were similar in the two groups.
• Researchers observed that the mean percent change in the urinary albumin/creatinine ratio from baseline to 48 weeks was similar in the two groups (P=.804).
• In the safety analysis, it was demonstrated that the withdrawal rates for adverse events were similar in both groups.