Sanikini H, et al. - Using 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort, researchers assessed anthropometric and reproductive factors relative to esophageal and gastric cancer by subtype and subsite. They found that men and women showed a correlation between body mass index and esophageal adenocarcinomas (EA); these links were weakened after adjustment for waist-to-hip ratio (WHR). In men and women, WHR and waist circumference (WC) were related to EA. Findings revealed a positive association of WHR with gastric cardia (GC) in women. Men showed a positive association of WC with GC. They noted inverse links between parity and EA and age at first pregnancy and gastric non-cardia (GNC); a positive relation of bilateral ovariectomy with GNC was also found. In this study, hormonal pathways were shown to have a role in upper gastrointestinal cancers.