Sallam M, Batarseh R, Natsheh A, et al. - Researchers retrospectively queried the electronic and paper-based clinical data registry records from 2007 to 2018 at the Jordan University Hospital (JUH) for individuals with hepatitis C virus (HCV) genotype, HCV viral load, and alanine aminotransferase (ALT) testing results in order to ascertain the genotype distribution among HCV clinical isolates in Jordan during this time period. For the final analysis, there was the availability of genotyping results of a total of 263 out of 342 unique individuals (76.9%), with 259 individuals each having a single genotyping result. They identified the predominance of genotype 4 among the cases followed by genotype 1. They identified higher viral load among individuals infected with genotype 1 vs those infected with genotype 4. Younger HCV-infected individuals (< 52 years) vs older individuals showed higher ALT levels. For HCV acquisition, self-reported risk factors were: history of previous surgery, invasive dental procedures, and blood transfusion, delivery at home, circumcision at home and wet cupping therapy (hijama). Given the poor response of both genotypes to traditional therapies, they emphasize implementing newer treatment and preventive strategies. They noted a large genetic diversity of the virus indicating the possibility of multiple introductions of HCV over a long period of time.