de Kuijper GM, et al. - Given the risks associated with long-term prescribing of off-label antipsychotics in people with intellectual disability, researchers evaluated potential causes of successful and failed discontinuation. They noted a lower prevalence of complete discontinuation in association with autism, higher dose of antipsychotic drug, higher Aberrant Behavior Checklist (ABC) and akathisia scores, and more-frequent worsening of health during discontinuation. So, in a selected sample of patients that clinicians thought discontinuation of antipsychotics could be attempted, discontinuation was achieved and maintained in 40% by end of follow-up. They recommend that physicians address patients’ conditions that could hinder discontinuation.