Bornstein NM, et al. - In this international, randomized, double-blind, sham-controlled, pivotal trial involving 1,078 patients, researchers ascertained if sphenopalatine ganglion stimulation 8–24 hours following acute ischemic stroke can improve functional outcomes. Via web-based randomization, enrolled subjects were randomly assigned to receive active sphenopalatine ganglion stimulation (intervention group) or sham stimulation (sham-control group) 8–24 hours following stroke onset. For patients with acute ischemic stroke 8–24 hours after onset who are not eligible for thrombolytic therapy, sphenopalatine ganglion stimulation is safe and is likely to improve functional outcome among patients with cortical involvement, though the evidence does not reach significance.