Xu W, Zhang X, Zhu Y, et al. - This study was conducted for analyzing the risk factors for non-idiopathic scoliosis with intramedullary abnormalities, explored the feasibility of whole-spine MRI, and served a theoretical basis for the routine diagnosis and treatment of adolescent idiopathic scoliosis. Between July 1, 2013, and December 31, 2018, researcher examined the clinical data of adolescent scoliosis patients who were admitted to Shanghai Tongren Hospital and Shanghai Changhai Hospital. The patients were classified into either the idiopathic group or the intramedullary abnormality group according to the whole-spine MRI results. Researchers compared gender, age, main curvature angle, main curvature direction, kyphosis angle, scoliosis type, coronal plane balance, sagittal plane balance, abdominal wall reflex, sensory abnormality, ankle clonus and tendon reflexes between the two groups. This study enrolled a total of 714 adolescent scoliosis patients with a mean age of 13.5 (10–18 years). The results of this study indicated that risk factors correlated with adolescent scoliosis caused by abnormal intramedullary abnormalities involved male gender, thoracic scoliosis on the left side, sharp curvature of the spine, abnormal abdominal wall reflex and ankle clonus. It was noted that the incidence of scoliosis caused by intramedullary abnormalities was approximately 9.5% in adolescent scoliosis individuals. The data demonstrates that these clinical indicators imply that there is a high-risk adolescent scoliosis population who should undergo whole-spinal MRI preoperatively to rule out intramedullary abnormalities.