Matsuhiro Y, Nishino M, Ukita K, et al. - Given that a conventional algorithm for estimating left ventricular (LV) filling pressure in heart failure is recommended by the American Society of Echocardiography / the European Association of Cardiovascular Imaging, but many patients are grouped as “indeterminate” because of their LV filling pressures being impossible to estimate, therefore, researchers determined if their new echocardiographic algorithm could predict clinical results among patients suffering from heart failure with preserved ejection fraction (HFpEF). A total of 754 consecutive patients were divided, using the new algorithm, into two groups; a normal LV filling pressure group (N group) and a high LV filling pressure group (H group). Multivariable Cox analysis revealed that being in the H group, vs the N group, was significantly related to an elevated rate of cardiac events. Using the conventional algorithm, 56 patients (7%) were assigned to “indeterminate”. The use of the new algorithm enabled reclassification of 16 patients (29%) into the H group and 40 patients (71%) into the N group. Kaplan-Meier curves demonstrated that a significantly higher incidence of cardiac events was present in the reclassified H group vs those assigned to the N group. Overall, experts inferred that clinical results in patients with HFpEF can be predicted by LV filling pressure evaluated by their algorithm.