Jiang HY, et al. - Considering the recent establishment of close relationships between gut microbiota and some mental disorders, researchers undertook a systematic comparative analysis of the gut microbiome in patients with generalized anxiety disorder (GAD) and healthy controls (HCs). A cross-sectional study of 40 patients with GAD in the active state and 36 HCs, was performed and to validate the results, a subgroup analysis consisting of 12 antidepressant-naive patients and 22 controls was undertaken. Finally, in a subgroup of nine patients with GAD who underwent analysis in the active state of anxiety and in remission, they conducted a prospective study. As per findings, GAD patients displayed microbiota dysbiosis of gut microbiota, suggesting the value of targeting the microbiome as the therapeutic and preventive target for GAD.