Wils J, et al. - Researchers evaluated the part played by NO and CYP450 epoxygenases-derived epoxyeicosatrienoic acids (EETs) in regulating endothelium-dependent flow-mediated dilatation of conduit arteries throughout aging. They found an independent and negative correlation of the magnitude of flow-mediated dilatation with age, baseline artery diameter and systolic blood pressure, and positive correlation was observed with the increase in shear stress induced by heating. Until the age of 35-40 years, an increase in nitrite level during heating was seen, which declined afterwards. Findings suggested that aging contributes to the development of endothelial dysfunction by impairing the availability of EETs and NO and epoxyeicosatrienoic acids in peripheral conduit arteries.