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All-cause and cause-specific mortality from restrictive and obstructive spirometric patterns in Chinese adults with and without dyspnea: Guangzhou Biobank Cohort Study

Respiratory Medicine May 03, 2019

Pan J, et al. - In Chinese adults with and without dyspnea, researchers investigated if abnormal spirometric patterns were related to differential mortality. Based on spirometric patterns and presence of dyspnea, the categorization of Guangzhou Biobank Cohort Study participants was done into 6 groups: normal spirometry, restriction on spirometry (ROS) and airflow obstruction (AO), each with and without dyspnea. Cox models were used to calculate adjusted hazard ratios for mortality. Increased all-cause and cardiovascular disease mortality were observed in relation to both ROS and AO, with and without dyspnea. For AO, a greater increased risk of all-cause mortality and a lower risk of cardiovascular mortality was reported, compared to that reported for ROS. A significantly increased risk of lung cancer was demonstrated by AO but not by ROS.
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