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Alcohol‐induced impaired insulin secretion in a Japanese population: 5‐year follow up in the Gifu Diabetes Study

Journal of Diabetes Investigation May 08, 2020

Ueda N, Yamamoto M, Nakamura M, et al. - Researchers conducted this retrospective study to determine the impact of daily alcohol consumption on glucose tolerance and diabetes development risk in Japanese populations. In addition, they assessed the 5‐year changes in hemoglobin A1c levels. For this investigation, they randomly registered 452 men and 659 women aged 40–78 years in 2005 (Gifu, Japan). Study participants completed a 75‐g oral glucose tolerance test and medical questionnaire. Data reported that the adjusted odds ratios for elevated homeostasis model assessment of β‐cell function values (< 40%) in the 0–19.9 g/day, 20.0–39.9 g/day and ≥ 40 g/day alcohol consumption groups, respectively, were 0.98, 1.46 and 2.68. The 5‐year risk of elevated hemoglobin A1c levels (≥ 6.5%) has been increased as a result of increased alcohol intake in both men and women. Overall, the authors concluded that regular alcohol intake in Japanese populations was associated with decreased insulin secretion and an increased risk of developing diabetes.

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