Che T, et al. - Researchers determined the efficacy and acceptability of agomelatine vs fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus (T2DM) subjects. The data of the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) were gathered to evaluate the depressive and anxiety symptoms, respectively. Results of this study suggested that fluoxetine, as well as, agomelatine could effectively decrease depressive and anxiety symptoms in T2DM subjects. However, agomelatine could be more effective and acceptable.