Lin H, Ding Y, Ning C, et al. - Researchers examined the link between HIV infection and subclinical atherosclerosis as evaluated by carotid artery intima-media thickness, while controlling for the effects of traditional risk factors as operationalized by the Framingham risk score (FRS). In this cross-sectional study, they assessed data from the baseline assessment of the Comparative HIV and Aging Research in Taizhou (CHART) cohort, an ongoing longitudinal study being performed in Zhejiang province, China. The analysis revealed subclinical atherosclerosis in 480 of 1,425 HIV-positive and 784 of 2,850 HIV-negative individuals. After stratifying by age, HIV-positive vs HIV-negative individuals had a higher prevalence of subclinical atherosclerosis across the age groups 18–29 years, 30–44 years, and 45–59 years, but not 60–75 years. Observations revealed an association of HIV infection with subclinical atherosclerosis, independent of classic risk factors. Given the stronger association at younger ages, early onset of subclinical atherosclerosis is suggested among young adults. In view of these findings, they emphasized modifying HIV/AIDS treatment guidelines to include cardiovascular evaluation in China.