Voisine M, Hervault M, Shen M, et al. - Researchers determined how age, gender, and valve phenotype [tricuspid aortic valves (TAVs) vs bicuspid aortic valves (BAVs)] can influence fibro‐calcific remodeling in calcific aortic valve disease. For this purpose, they analyzed 2 cohorts: 411 patients who underwent multidetector computed tomography (37% women) for aortic valve calcification density evaluation and 138 explanted aortic valves (histological cohort; 50% women). Experts categorized the cohorts in younger (< 60 years old) or older patients having BAV (≥ 60 years old), and TAV patients. Findings revealed less calcification and more fibrotic remodeling among women vs men, irrespective of the phenotype of the valve or age of the patient, in calcific aortic valve disease. Moreover, less valve calcification was seen in younger women with BAVs. Therefore, mineralization/fibrosis of the aortic valve possibly have gender/age‐specific mechanisms and may be impacted by the valve morphology.