Agarwal A, Thombley R, Broberg CS, et al. - Researchers used the 2010-2016 IBM MarketScan commercial claims database to estimate the comorbidity burden among US adults with congenital heart disease (CHD). Adults with CHD were frequency matched to CHD-free adults within classes collectively defined by age, sex, and dates of enrollment in the database. According to findings, the likelihood of having any comorbidity was nearly two-fold in adults with CHD vs those without CHD. Following adjustment for covariates, adults with CHD demonstrated a higher prevalence risk ratio for “previously recognized to be common in CHD”, “other cardiovascular”, and “noncardiovascular” comorbidities. Individuals with severe CHD demonstrated higher risks of previously recognized to be common in CHD and lower risks of other cardiovascular comorbidities vs age-stratified patients with non-severe CHD— following adjustment for covariates and considering interaction with age. For noncardiovascular comorbidities, the risk was higher among patients with severe vs non-severe CHD prior to, but not following, the age of 40 years. Overall, the researchers’ findings highlight the clinical needs of individuals with CHD. Healthcare providers of patients with CHD may benefit from the use of a multidisciplinary approach, including building close collaborations with internists and specialists, to help provide appropriate care for the highly prevalent noncardiovascular comorbidities.