Agarwal A, Thombley R, Broberg CS, et al. - Researchers estimated comorbidity burden among the US adult patients with congenital heart disease (CHD) using the 2010-2016 IBM MarketScan commercial claims database. They frequency matched cases with adults without CHD within classes jointly defined by age, sex, and dates of enrollment in the database. The likelihood of having any comorbidity was nearly twice in adults with CHD vs those without CHD. A higher prevalence risk ratio for “previously known to be common in CHD”, “other cardiovascular”, and “noncardiovascular” comorbidities was found in patients with CHD, after adjusting for covariates. With regard to noncardiovascular comorbidities, a higher risk was noted in patients with severe vs nonsevere CHD prior to, but not following, the age of 40 years. Overall, the unique clinical requirements of adults with CHD vs their peers was emphasized. In order to offer suitable care for the highly prevalent noncardiovascular comorbidities, a multidisciplinary approach, including building close collaborations with internists and specialists may be preferred by clinicians caring for CHD.