Kumar A, Sammour Y, Reginauld S, et al. - Given the lack of data concerning the optimum timing of percutaneous coronary intervention (PCI) in relation to transcatheter aortic valve replacement (TAVR). Researchers here compared patients who underwent PCI before TAVR with those who received PCI with/after TAVR with respect to the occurrence of major adverse cardiovascular and cerebrovascular events. In this multicenter study, they included 3,982 patients who underwent TAVR; of these patients, 327 (8%) underwent PCI within 1 year before TAVR, 38 (1%) had PCI the same day as TAVR and 15 (0.5%) had PCI within 2 months after TAVR. Among patients who underwent both PCI and TAVR, history of CABG, higher BMI, and statin therapy were independently associated with lower adverse event rates, while warfarin therapy after TAVR was associated with higher adverse event rates. Similar adverse events rates were noted regardless of timing of PCI.