Franzoi MA, Rosa DD, Zaffaroni F, et al. - As young women do not commonly present with breast cancer (BC) and tend to exhibit more aggressive characteristics, researchers sought to better understand and characterize this scenario in Brazil via performing a subanalysis of AMAZONA III study. From 2,950 women newly diagnosed with invasive BC that were described in the AMAZONA III study (GBECAM 0115), a prospective registry in Brazil, they obtained valid data from 2,888 patients concerning the age at diagnosis and complete baseline information. The analysis revealed unfavorable clinicopathological features of BC with more aggressive subtypes and advanced stage when compared with older women in Brazilian women younger than age 40 years at diagnosis. Socioeconomic or ethnic imbalances do not explain these differences. Additional investigation is recommended to determine the causes of a higher prevalence of BC among young women in Brazil.