El Kamari V, et al. - Researchers conducted a cross-sectional study involving 90 individuals (68 HIV+ and 22 healthy controls matched by age and sex) comparing HIV-infected patients and uninfected controls regarding levels of advanced glycation end products (AGEs). In addition, they assessed the relationship between AGEs, HIV, inflammation, and endothelial dysfunction. Using 3 different modalities, they assessed AGE levels: free AGEs were measured in the serum, skin autofluorescence (AF) was determined with a noninvasive reader, and dietary AGEs were estimated using 24-hour dietary recalls. HIV-infected participants vs uninfected controls had significantly higher skin AF and serum AGEs. The HIV-infected group but not controls showed a significant association of skin AF and circulating AGEs with inflammatory and oxidative markers, and with markers of endothelial dysfunction. Intrinsic production of AGE is suggested in HIV-infected individuals. As per findings, AGEs seems to have potential implications in chronic inflammation and endothelial dysfunction in HIV. This suggests a new potential target for HIV-associated heightened inflammation and cardiovascular risk.