Qu D, et al. - In a clinical trial of a population of men who have sex with men (MSM), researchers evaluated the adherence to pre-exposure prophylaxis (PrEP). In addition, they aimed to explore the influence of social psychology and objective factors (eg, forgetting, too busy,) on adherence and to provide evidence for subsequent PrEP research. This study is based on a prospective cohort study, which has practical reference value. As per findings, objective factors “forgetting to take medicine” mainly influenced PrEP adherence. Risk perception, knowledge, motivation and self-efficacy were not identified influencing PrEP adherence.