Wong JCT, et al. - In a multicenter Asia-Pacific cohort to justify differential targets, researchers compared adenoma detection rate (ADR), advanced ADR (AADR), and a number of adenomas per colonoscopy (APC) in direct screening colonoscopy (DSC) vs fecal immunochemical tests-positive colonoscopy (FITC). From 8 sites across the Asia-Pacific region, asymptomatic average-risk patients ≥50 years of age who had screening colonoscopy directly or as follow-up for positive OC-Sensor FIT results were identified. Overall, the sex-specific ADR, AADR and APC were compared between the two screening methods. The data presented in this work showed a total of 2901 people had DSC and 2485 underwent FITC. In FITC, overall ADR, male-specific ADR, female-specific ADR and overall AADR were significantly higher than the corresponding DSC values. The study gives early evidence that newly proposed higher ADR targets are justified as FITC quality indicators.