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Addition of N-terminal pro-B natriuretic peptide to soluble fms-like tyrosine kinase-1/placental growth factor ratio > 38 improves prediction of pre-eclampsia requiring delivery within 1 week: A longitudinal cohort study

Ultrasound in Obstetrics & Gynecology Jun 11, 2018

Sabriá E, et al. - In this longitudinal prospective cohort study, the researchers assessed the effectiveness of N-terminal pro-B natriuretic peptide (NT-proBNP), uric acid and the soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio for prediction of delivery with pre-eclampsia (PE) within 1 week in singleton pregnancies with suspected PE and sFlt-1/PlGF ratio > 38. Ultimately analysis of 270 blood samples from 134 patients was done out of 495 enrolled patients. When the sFlt-1/PlGF ratio was > 38, the addition of NT-proBNP assessment improves the short-term prediction of delivery as a result of PE compared with sFlt-1/PlGF ratio alone.
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