Uruska A, et al. - Using an AGE Reader, researchers assessed the relationship between skin advanced glycation end products and insulin resistance in type 1 diabetes. Study participants included 476 individuals with type 1 diabetes (247 men) with a median age of 42 (33–53) years, disease duration of 24 (19–32) years and HbA_1c concentration of 63 (55–74) mmol/mol. In people with type 1 diabetes, strong evidence was found for a two-way relationship between insulin resistance and advanced glycation product accumulation in the skin. There was a negative correlation between skin autofluorescence and estimated glucose disposal rate.