Jeuring HW, et al. - The six-year prognosis of patients with late-life depression was examined. In addition, prognostic factors of an unfavorable course were investigated. Researchers conducted the Netherlands Study of Depression in Older persons (NESDO) which is a multi-site naturalistic prospective cohort study with six-year follow-up. Late-life depression was noted to have poor long-term prognosis in terms of mortality and course. Depression in later life is a chronic and disabling disorder, in which treatment is probably still suboptimal. They noted an unfavorable course in association with a younger age of onset of depression, higher baseline depression, chronic pain, neuroticism and loneliness. Interventions targeting chronic diseases and loneliness might valuable for patients with a partial remission. They recommend improving prevention and treatment strategies, considering the poor prognosis and high dropout among depressed older patients in this study.