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A SEER population analysis of stage IB resected gastric cancer: Who can benefit from adjuvant therapy?

Journal of Global Oncology Oct 21, 2019

Wang Y - Experts retrospectively involved 1,935 individuals with stage IB gastric cancer (GC) who underwent curative surgery from the SEER database between 2004 and 2015 in order to propose a reference for the rational indications of adjuvant therapy (AT). In the nomogram, five variables, which were significantly correlated with overall survival (OS) of AT, were involved ie, gender, age, examined lymph nodes, tumor site, and family income. The decision curve showed that when the threshold probability was 0-47%, the optimal clinical influence was accomplished. On the basis of the projected 5-year OS, the entire cohort was then classified into low-risk (≤ 107 points) as well as high-risk ( > 107 points) groups. For high-risk individuals, group surgery alone vs Group AT exhibited a significantly poorer OS and on the other hand, there was a similar OS for low-risk individuals. Hence, an efficient, intuitional and applied prognostic tool on the basis of a nomogram to clinical decision-making was developed. AT, for stage IB GC following surgical resection, was only suggested for high-risk individuals. Nonetheless, for low-risk individuals, AT could be unnecessary.
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