Abreu M, et al. - In patients with very uncontrolled type 2 diabetes, researchers compared the safety and effectiveness of a GLP-1 receptor agonist (GLP1RA) plus basal insulin vs basal-bolus insulin treatment. The study sample consisted of 120 candidates (47.4±9.5 years). Compared to basal-bolus insulin, HbA1c≥10% treatment with GLP1RA plus basal insulin resulted in better glycemic control and weight, a lower dosage of insulin and hypoglycemia, and improved quality of life. This strategy of treatment is an effective and safe alternative to basal-bolus insulin regimen.