Núñez J, Llàcerc P, García-Blas S, et al. - Through a multicenter, open-label study randomized 160 patients with acute heart failure and renal dysfunction, experts ascertained whether a CA125 guided diuretic strategy was better than usual care in terms of short-term renal function in patients with acute heart failure and renal dysfunction at presentation. The CA125-guided group received greater furosemide equivalent dose in comparison with usual care, which changed into higher urine volume, over 72 h. Furthermore, patients in the active arm with CA125 > 35 U/mL received the greatest furosemide equivalent dose and had higher diuresis. At 72-h, eGFR significantly progressed in the CA125-guided group with no important variations at 24-h. In conclusion, in patients with acute heart failure and renal dysfunction, eGFR and other renal function parameters were markedly enhanced by CA125-guided diuretic strategy at 72 h.