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A randomised phase II trial of capecitabine plus cisplatin vs S-1 plus cisplatin as a first-line treatment for advanced gastric cancer: Capecitabine plus cisplatin ascertainment vs S-1 plus cisplatin randomised PII trial (XParTS II)

European Journal of Cancer Aug 23, 2018

Nishikawa K, et al. - In this phase II trial, experts compared capecitabine plus cisplatin (XP) with S-1 plus cisplatin (SP) in patients with advanced gastric cancer (AGC) to see if these regimens can be used as controls in a phase III study. They also explored whether histological subtypes favor XP or SP. Findings suggested a comparability of XP and SP, and these can be recommended as control arms in a phase III study for AGC. For the selection of XP or SP, histological subtypes were not sensitive markers.

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