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A prospective, randomized, multicenter study comparing silicated calcium phosphate vs BMP-2 synthetic bone graft in posterolateral instrumented lumbar fusion for degenerative spinal disorders

Spine Jul 17, 2018

Coughlan M, et al. - Researchers compared the vertebral fusion success rates following posterolateral fusion [(PLF)/posterolateral intertransverse fusion (PITF)] surgery. Posterior lumbar interbody fusion (PLIF) and PLF with internal fixation were combined by the surgical procedure over one or two levels using silicated calcium phosphate (SiCaP) or bone morphogenetic protein (BMP)-2 as graft material in patients with a degenerative disorder of the lumbar spine. In patients with degenerative spinal disorders requiring PLF, SiCaP was safe and well tolerated. It provided fusion rates similar to BMP-2. With this surgical population, adverse events (AEs) were consistent.
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