Sabesan VJ, et al. – This prospective randomized controlled trial evaluated the effect of liposomal bupivacaine (LB) compared with continuous interscalene nerve block (CISB) in terms of postoperative pain control, outpatient pain scores, and patient–reported and functional outcomes after shoulder arthroplasty surgery. The physicians revealed that for shoulder arthroplasty patients, LB provides excellent postoperative pain relief. Moreover, LB had fewer complications and lower cost, making it a promising addition to a multimodal pain regimen for shoulder arthroplasty.