Hu C, Zhang Q, Jin X, et al. - Obesity and weight management have been shown to play a role in colorectal cancer (CRC) recurrence and survival, so researchers assessed if a change in weight affects the risk of recurrence and death in CRC by examining the effect of preoperative BMI and change in weight during postoperative chemotherapy on disease-free survival (DFS) and overall survival (OS). They enrolled 902 patients with stage II and III CRC. Preoperative BMI and change in weight played bidirectional roles in both the OS and DFS, as seen in multivariable Cox proportional hazards models. According to this retrospective study, there is an obesity paradox in patients with CRC, with both weight loss and excessive weight gain being harmful. A reasonable weight management program may be needed for patients with CRC, and gaining ˂ 5% of the preoperative weight may be an appropriate goal at 6 months after surgery. Patients who had a normal weight or had weight gain of < 5% had the lowest risk of cancer events (recurrence/metastasis and new CRC cases) and death. Patients who were underweight or overweight/obese and had weight loss or weight gain of ≥ 5% had a higher risk of cancer events and death.