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A novel risk stratification score for sudden cardiac death prediction in middle-aged, nonischemic dilated cardiomyopathy patients: The ESTIMATED score

Canadian Journal of Cardiology Apr 10, 2020

Li X, Fan X, Li S, et al. - So that sudden cardiac death (SCD) in patients with nonischemic dilated cardiomyopathy (NIDCM) and left ventricular ejection fraction ≤ 35% may be predicted, researchers tried to construct a risk score (LG E Ba sed Predic tion of SCD Risk in Nonische mic Dil ated Cardiomyopathy [ESTIMATED]) based on late gadolinium enhancement (LGE) cardiac magnetic resonance in this study. A total of 395 consecutive middle-aged patients with NIDCM were recruited and a 3-year follow-up for SCD events was conducted in the participants. In the derivation as well as in validation set, good calibrations for SCD prediction were displayed by the ESTIMATED score (developed by the LGE extent > 14%, syncope, atrial flutter/fibrillation, nonsustained ventricular tachycardia, advanced atrioventricular block, and age ≤ 20 or > 50 years). For 3-year SCD events, the score classified 20.3% of primary prevention patients as high risk (≥ 3 points), 28.1% as intermediate risk (2 points), and 51.6% as low risk (0-1 points). Overall, refined SCD prediction was afforded by an LGE-based (ESTIMATED) risk score derived as well as validated in this study. The score may aid to recognize candidates for primary prevention implantable cardioverter-defibrillator among patients having NIDCM.

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